Sean Ono Lennon was born at Weill Cornell Medical Center in Manhattan, New York City, on 9 October 1975, his father's 35th birthday.

[8][9] In October 1984, when Steve Jobs was visiting Manhattan, he attended Ono Lennon's birthday party and gave him one of the first Macintosh computers as a present.

From childhood into his teen years, Ono Lennon continued to collaborate with his mother, contributing vocals and receiving production credit on her solo albums It's Alright, Starpeace and Onobox.

By 1995 Ono Lennon had formed the band IMA (with Sam Koppelman and Timo Ellis) to play alongside his mother on her album Rising.

In 2000, Ono Lennon contributed vocals to Del tha Funkee Homosapien (a single stanza on the Deltron 3030 track "Memory Loss"), Handsome Boy Modeling School and Jurassic 5.

The videos were actually screen tests for Coin Locker Babies, another project on which Ono Lennon was working which became a cinematic counterpart to his new album.

The night the album was released, Ono Lennon made his first major television appearance in five years, performing "Dead Meat" live on the Late Show with David Letterman.

Since the release of Friendly Fire, Ono Lennon has toured extensively around the world and while in France, he remixed his song "Parachute" in collaboration with French artist -M-.

Muhl and Ono Lennon premiered the band the Ghost of a Saber Tooth Tiger[17] during a live performance at Radio City on Valentine's Day, 2008.

The following year, the new group released their debut album, Monolith of Phobos, which reached the Top 10 of three Billboard charts, followed by a covers EP titled Lime and Limpid Green in 2017.

While reestablishing himself as a solo artist, Lennon continued his work as a session musician and producer, lending his talent to the likes of Dopo Yume, Albert Hammond, Jr. (of the Strokes) and model/singer Irina Lăzăreanu.

[24] Lennon also lent his production and songwriting talents to Lana Del Rey's fifth studio album Lust for Life, where he featured on the track "Tomorrow Never Came".

Lennon entered the field of film scores in 2009 with Rosencrantz and Guildenstern Are Undead, directed by long-time friend and school mate Jordan Galland.

[28] Along with girlfriend Charlotte Kemp Muhl, Lennon started a record label, Chimera Music, which has signed a number of his collaborators including the Moonlandingz, Cibo Matto and Yoko Ono.

[33][34] On August 28, 2012, Ono Lennon's opposition to hydraulic fracking was published as an op-ed article, "Destroying Precious Land for Gas", by The New York Times.

Methane is 100 times more powerful of a greenhouse gas than carbon dioxide and most people don't realize how climate change will be triggered by a globalized fracking industry.

Over 200 artists have signed onto the initiative, including Mark Ruffalo and Anne Hathaway, as well as Beatles' members Paul McCartney and Ringo Starr.

"[36] On October 16, 2013, Ono Lennon, along with Spacehog and Liv Tyler, played "Live on Earth" – an Internet-only performance – to benefit the David Lynch Foundation, which funds the teaching of Transcendental Meditation.

[39][40] Of his own practice of Transcendental Meditation, in 2014, Ono Lennon said that "for me, it's like a scientific method to calm my brain down and making my frontal lobe more active.

"[41][better source needed] Ono Lennon is in a relationship with Charlotte Kemp Muhl, whom he met at the Coachella Valley Music and Arts Festival in 2005.

[42] In an interview, Ono Lennon states he stumbled upon Muhl's musical talents over a year after they had started dating, and formed The Ghost of a Saber Tooth Tiger around 2008.

[43] Muhl and Ono Lennon are involved in several musical endeavors[44] and much of their work is written at their home-based studio in Greenwich Village, New York.