He is best known for playing the villain Sonny Appleday in the Cartoon Network TV film Re-Animated and its spinoff series Out Of Jimmy's Head.

After spending five years sailing to ports in Europe, Africa, Central America and the Far East and successfully navigating through both the Suez and Panama canals, he eventually settled down in Los Angeles and began an entertainment career.

Matt's also been a part of several high-profile commercial campaigns for Volkswagen, DirecTV, Pepsi, Apple, GE and others; which have aired during the Super Bowl and the Olympics.

As a stand-up, he has appeared on Conan, The Late Late Show, Last Call, ASX Live and Comics Unleashed as well as several festivals, including The San Francisco Sketchfest, Bridgetown, Limestone, High Plains, Laughing Skull, Big Sky, and the Just for Laughs Festival in Montreal; where he was named a "Best of the Fest."

His critically acclaimed albums The Comedy Stylings of Matt Knudsen and American became top downloads on iTunes, heard regularly on SiriusXM radio, and have been described as mixing "droll observation with a dry, almost hypnotic delivery," (The Onion A.V.