He is most commonly recognized as the ex-husband of singer and actress Olivia Newton-John, and for his acting in films such as My Tutor and the soap opera Paradise Beach.

McDermott disappeared in 2005, and was subsequently declared by the United States Coast Guard to have been lost at sea.

[9] In 2008, Lattanzi briefly appeared in the MTV reality series Rock the Cradle, supporting his daughter Chloe (a contestant on the show).

Other film credits include Rich and Famous, Grease 2, That's Life!, Roxanne, Catch Me If You Can, and Diving In.

Lattanzi also had a significant role in the Australian soap opera Paradise Beach,[11] and he appeared in eight of Newton-John's music videos: "Xanadu", "Hollywood Nights", "Gimme Some Lovin'", "Landslide", "Soul Kiss", "Toughen Up", "It’s Always Australia For Me", and "Can't We Talk It Over in Bed".