His mother, Patricia (née Di Cillo), was an office manager; his father, Paul LeBlanc, was a mechanic and a veteran of the Vietnam War.

He played Vinnie Verducci, a family friend of protagonist Al Bundy (Ed O'Neill) who briefly dates his daughter, Kelly (Christina Applegate).

[8] He also appeared in videos for Alanis Morissette's single "Walk Away," Tom Petty & The Heartbreakers's "Into The Great Wide Open" and Bob Seger's "Night Moves".

Friends was wildly successful, and LeBlanc (along with co-stars Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matthew Perry, and David Schwimmer) gained wide recognition among viewers.

This ensemble situation comedy became a major hit for NBC, airing on Thursday nights for ten years.

Following the cancellation of Joey, LeBlanc announced that he would be taking a one-year hiatus from acting on television, which eventually turned into five years.

[16] In February 2012, LeBlanc appeared in the second episode of the eighteenth season of Top Gear, where he set the fastest lap time in the "Star in a Reasonably Priced Car" segment in a Kia Cee'd.

[9] He also appeared in the fourth episode of the nineteenth season to race the New Kia Cee'd, and beat his previous time.

[19] He and Rory Reid were replaced by new co-hosts Paddy McGuinness and Andrew Flintoff in the twenty-seventh series in October 2018.

LeBlanc played the lead role in the CBS sitcom Man with a Plan, which began airing in 2016 until it was cancelled in 2020.