For his work on Broadway, Shalhoub won the Tony Award for Best Actor in a Musical for his performance as Tewfiq Zakaria in The Band's Visit in 2018.

Anthony Marc Shalhoub (Arabic: أنتوني مارك شلهوب), the ninth of ten children, was born and raised in a Lebanese Christian household[2] in Green Bay, Wisconsin.

Shalhoub attributed his therapy as an adult to that emotional restriction but has stated that it enabled him to play calm and relaxed roles in his career.

[5] His father, Joseph (1912–1991),[6] was from Zahle, Lebanon while it was still part of the Ottoman Empire and immigrated to the United States as a child after his own parents, Milhem and Mariam, died during World War I.

[1][a] One of Shalhoub's maternal great-great-grandfathers, Abdul Naimy, although Lebanese, was reportedly killed by being crucified in 1895 during the Hamidian massacres committed against Christian Armenians in the Ottoman Empire.

[3][10] Shortly after graduating from Yale, Shalhoub moved to Cambridge, Massachusetts, where he spent four seasons with the American Repertory Theater before heading to New York City, where he found work waiting tables.

He made his Broadway debut in the 1985 Rita Moreno/Sally Struthers production of The Odd Couple and was nominated for a 1992 Tony Award for his featured role in Conversations with My Father.

[12] In 1998, Shalhoub starred in The Classic Stage Company's production of Waiting for Godot alongside John Turturro and Christopher Lloyd.

Shalhoub had a co-starring role in the film Big Night (1996), as one in a pair of Italian immigrant brothers who own a struggling ethnic restaurant.

In 1995 he had a role in the hit NBC sitcom Frasier in the episode "The Focus Group" as an Arab newsstand owner named Manu Habbib.

Shalhoub demonstrated his dramatic range in the 1998 big-budget thriller The Siege, where he co-starred alongside Denzel Washington, Annette Bening, and Bruce Willis.

His character, FBI Special Agent Frank Haddad, also a Lebanese American, suffered discrimination after terrorist attacks in New York City.

[17] Shalhoub returned in December 2006 to the Off-Broadway Second Stage Theatre, opposite Patricia Heaton for a run of The Scene by Theresa Rebeck.

[22] He was nominated for a 2013 Tony Award for Best Performance by a Featured Actor in a Play for Lincoln Center Theater's production of Golden Boy at the Belasco Theatre.

[23] He was nominated for a 2014 Tony Award for Best Performance by a Leading Actor in a Play for Lincoln Center Theater's production of Act One at the Vivian Beaumont Theatre.

[29] Shalhoub stars as Jewish-American math professor Abe Weissman, father of protagonist Midge Maisel (Rachel Brosnahan), in the Emmy-winning, Amazon-produced television comedy series The Marvelous Mrs.