He graduated from the Rhode Island School of Design in 2005, earning a Bachelor of Fine Arts degree.
He has stated that his use of enamel and the color blue references utilitarian applications in municipal and industrial settings, such as mailboxes and dumpsters.
In the 2018 monograph Blue Paintings,[2] published by Denny Dimin Gallery, curator Aaron Levi Garvey analyzed Mignanelli's work, noting its focus on contrasts between structured daily life and moments of subconscious exploration.
He has lectured at Parsons School of Design and appeared in the 2013 season of VICE Magazine's Art Talk video series.
In 2008, he worked alongside director Michel Gondry on Björk's music video "Declare Independence" in which he is shown painting.