Matthew O'Donnell (born March 26, 1989) is a former professional Canadian football offensive lineman who played for ten years with the Edmonton Eskimos (Edmonton Elks) franchise of the Canadian Football League (CFL).

On December 17, 2010, it was announced that O'Donnell was one of two CIS players to be named to the East–West Shrine Game.

On May 31, 2011, it was reported that O'Donnell had chosen to delay his signing with the Roughriders due to the NBA's Boston Celtics put him through a workout session in June.

[3] O'Donnell also received interest from the Toronto Raptors and he attended a workout in June 2011.

[4] On July 26, 2011, O'Donnell signed a contract with the Cincinnati Bengals one day after the 2011 NFL Lockout.