O'Dwyer played in the NFL for the New York Jets (1995–1998), the Cincinnati Bengals (1999–2003), and the Tampa Bay Buccaneers (2004).
[1] He blocked on lines that produced a 1,000-yard rusher in seven of his 10 NFL seasons (Adrian Murrell 1996–1997, Curtis Martin 1998 and Corey Dillon 1999–2002).
He also helped Dillon to break Walter Payton's single-game NFL record, a 278-yard performance vs. Denver, October 22, 2000 (since surpassed by Jamal Lewis in 2003 and Adrian Peterson in 2007).
[3] After playing for the Buccaneers in 2004, O'Dwyer was signed by the Green Bay Packers in 2005, but he was cut at the beginning of the season.
O'Dwyer appeared in the Jon Favreau & Vince Vaughn movie Made with fellow NFL player Jason Fabini & future The Sopranos star Federico Castelluccio as doormen.