Matt Scott was born in Detroit, Michigan, where he began playing wheelchair basketball with the Sterling Heights Challengers in the NWBA Junior Division.

[6] Scott continued his professional career with Comune Di Porto Torres in Italy for two seasons from 2014 to 2016, during which time Scott's game film of him making multiple three-point shots in front of a crowded arena went viral, prompting the sports blog The Undefeated to publish a write-up titled "Meet the Steph Curry of Wheelchair Basketball.

Scott then returned to RSB Thuringia where he and Team USA teammate Jake Williams helped the Bulls win the IWBF Champions Cup in 2018 and 2019.

He was the first US Paralympian to star in a Nike, Inc. advertisement, "No Excuses", where the viewer is made unaware of his disability until the camera zooms out to show his basketball wheelchair at the end.

[10] Scott has also been a spokesperson for Travel Wisconsin, participated in a digital marketing campaign for the Apple Watch, and has been an athlete ambassador for Ralph Lauren.