He played in Major League Baseball (MLB) for the Seattle Mariners, Detroit Tigers, and Braves.

[citation needed] Tuiasosopo signed a professional baseball contract after graduating from Woodinville High School.

He began his pro career with the Peoria Mariners in 2004, hitting a solo home run in first career-at bat on July 10.

In 2006, he split time between the Mariners' High-A Inland Empire 66ers and Double-A San Antonio Missions affiliates.

On September 5, 2008, he collected his first major league hit, a double, against pitcher Andy Pettitte of the New York Yankees while playing for the Seattle Mariners.

[3] Tuiasosopo hit two home runs against the Portland Beavers on August 28 helping the Rainiers to their seventh straight victory.

On September 13 Tuiasosopo was called up to Seattle after the Rainiers lost in the first round of the playoffs to the Sacramento River Cats.

That was important to all of us in that room there.On September 27, during the pre-game show on 710 ESPN Radio, color man Mike Blowers predicted that Tuiasosopo would hit his first major league home run in his second at bat of the game on a 3–1 fastball into the left center field second level of Rogers Centre.

Sure enough, in the fifth inning of their game against the Toronto Blue Jays, Tuiasosopo delivered, although the home run went above the left field bullpen on technically what is the first level of the stadium.

Tuiasosopo signed a minor league contract with the New York Mets on January 27, 2012, and spent the season with the Triple-A Buffalo Bisons.

[13] On June 12, the Blue Jays traded Tuiasosopo to the Chicago White Sox for cash considerations.

Tuiasosopo spent the entire 2017 season in the minors with the Gwinnett Braves of the Triple-A International League, playing in 114 games.

On July 20, he made his first career pitching appearance in his 1,243rd minor league game, striking out two batters in a scoreless ninth inning against the Indianapolis Indians at Coolray Field.

[21] On May 21, 2018, Tuiasosopo signed with the New Britain Bees of the independent Atlantic League of Professional Baseball.

In 2020, with the Minor League Baseball season canceled, he coached at the Braves' alternate training site.

Their older sister Leslie Gabriel played volleyball at Washington, and is currently the head coach for the Huskies.