[3] The win qualified him for the 2009 Open Championship, where, playing alongside Tom Watson and Sergio García in the first two rounds, he made the cut and won the Silver Medal as leading amateur.

[6] On 9 April 2010, Manassero beat Bobby Cole's record, which lasted since 1967, to become the youngest player ever to make the cut at the Masters Tournament, at 16 years and 11 months and 22 days.

He was surpassed by Guan Tianlang who, on 12 April 2013, became the youngest player to make the cut in PGA Tour history at 14 years, 5 months of age.

At age 17, the victory made him the youngest-ever winner on the European Tour, surpassing the record set by Danny Lee at the 2009 Johnnie Walker Classic.

Manassero posted another very strong result when he tied for second in the 2010 UBS Hong Kong Open, one stroke behind winner Ian Poulter.

After collecting a 4th place at the 2014 Aberdeen Asset Management Scottish Open as the sole top 10 result of the season, 2015 proved to be a more difficult year for Manassero in the European Tour, where he was able to make only 6 cuts in 22 competitive starts.