[citation needed] Lowry was the 2007 Irish Amateur Close Champion, defeating Niall Turner 4 and 3 in the final.

[7][8] While still an amateur in May 2009, he won the Irish Open at County Louth Golf Club on the European Tour, defeating Robert Rock on the third hole of a sudden death playoff.

"[13] Lowry elected to turn professional the week after his Irish Open triumph, meaning that he would miss out on the opportunity to play in the Walker Cup in September 2009.

[15] Lowry missed the first three cuts of his professional career, but had his first payday on 5 July, when he finished 50th at the Open de France Alstom.

He shot a 67 to tie for the lead with the Englishman Ross Fisher, who made bogey on the final hole after missing a four-foot putt.

The victory lifted Lowry back into the Official World Golf Ranking top 100 and made him eligible to compete in the WGC-HSBC Champions.

[20] In August 2015, Lowry won the WGC-Bridgestone Invitational in the United States at Firestone in Akron, Ohio, two strokes ahead of runner-up Bubba Watson.

At the 2016 U.S. Open at Oakmont Country Club near Pittsburgh, Lowry shot 65 (−5) in the third round for 203 (−7) and a four-stroke advantage over Dustin Johnson and Andrew Landry at the 54-hole stage.

Due to weather delays on Thursday, the third round was not completed until early on Sunday, and Lowry birdied two of his remaining four holes to extend his two stroke overnight lead to four.

[25][26][27] Lowry held the Claret Jug for two years due to the COVID-19 pandemic postponing the 2020 edition of the Open Championship.

[28] In April, Lowry held the lead during the final round of the RBC Heritage, however a double-bogey on the back nine, saw him finish one shot short of the playoff between Patrick Cantlay and Jordan Spieth.

He beat Rory McIlroy and Jon Rahm (who shot a 62 in the final round) by one stroke for his sixth European Tour victory.

[30] In September 2023, Lowry played on the European team in the 2023 Ryder Cup at Marco Simone Golf and Country Club in Guidonia, Rome, Italy.

1Cancelled due to COVID-19 pandemic QF, R16, R32, R64 = Round in which player lost in match play NT = No tournament "T" = Tied Note that the Championship and Invitational were discontinued from 2022.