[4] Starting from 2016, Strukul published four historical novels set in Florence between the 15th and the 17th century, following the rise of the House of Medici,[5][6][7][8] which all became bestsellers in Italy.

[12] His work has been translated in over twenty languages[13] among which are English, French,[14] German,[15] Spanish,[16] Dutch,[17] Serbian[18] and Romanian.

[1] In Italy, Strukul also wrote Vlad, a comic book trilogy for Feltrinelli, with art by Andrea Mutti, focused on the historic character of Vlad the Impaler, the man whose story gave Bram Stoker the inspiration for the character of Count Dracula.

[23][24][25] It has been announced that Strukul will write the script for a videogame entitled Dark Renaissance, set in Italy, to be released in 2021.

[26][27] Matteo Strukul is also an adjunct professor of interactive storytelling at Link Campus University in Rome,[28] is a member of the Historical Novel Society[29] and writes in the cultural section of the weekly magazine Il Venerdì di Repubblica.