Although of deficient education he took a deep interest in literature and science, and especially devoted attention to the collection of documentary and pictorial illustrations of the history of Lancashire.
These he used in compiling his Portfolio of Fragments relative to the History and Antiquities of the County Palatine and Duchy of Lancaster, which he brought out in 1817 in three folio parts.
He was offered knighthood by the Prince Regent on presenting a copy of the book, but declined the dignity.
He had shown that paint, varnish, and printers' ink could be produced from burnt grain and sugar.
He was a most charitable and hospitable man, and his house, ever open to his acquaintances, acquired the title of "Gregson's Hotel".