He was a grandson of Matthew Talbot, who was the third son of the tenth Earl of Shrewsbury.

After the death of his wife, he moved to Bedford County, Virginia.

[1] From 1790 to 1791, Talbot served as superior court clerk in Elbert County.

[2] Talbot eventually moved to Oglethorpe County, Georgia and was elected its delegate to the state Constitutional Convention in 1795 and 1798.

In 1808, he was elected to the Georgia Senate and served in that capacity for fifteen years.