Matthews is a city in New Madrid County, Missouri, United States.

According to the U.S. Census Bureau, the city has a total area of 1.96 square miles (5.08 km2), all land.

[6] As of the census[8] of 2010, there were 628 people, 247 households, and 158 families living in the city.

There were 267 housing units at an average density of 136.2 per square mile (52.6/km2).

31.2% of all households were made up of individuals, and 14.5% had someone living alone who was 65 years of age or older.

There were 278 housing units at an average density of 252.1 per square mile (97.3/km2).

27.0% of all households were made up of individuals, and 14.3% had someone living alone who was 65 years of age or older.