[6] He made his debut for the team on 17 August 2019, appearing as a half-time substitute in a 1–1 draw away to Minnesota United.

He scored his first goal for the club on 20 July 2020 in a 1–1 draw against Philadelphia Union during the MLS is Back Tournament.

[8] Ahead of the 2022 season, Pereyra signed a new one-year DP contract with Orlando and was named captain following the offseason departure of Nani.

[9] On November 23, 2022, Orlando signed Pereyra to a new two-year contract using allocation money meaning he would no longer occupy a Designated Player slot.

[11] In December 2023, it was announced Pereyra would return to Nacional ahead of the 2024 Uruguayan Primera División season, 12 years after he originally departed the club.