On 20 January 1942, as a major air operation in Southeast Asia, the 62nd Sentai Heavy Bombers escorted by the 50th Sentai of Imperial Japanese Army Air Service attacked the airfield and its satellite at Mudon with a total of 65 planes.

On 14 March 1949, a De Havilland DH.104 Dove 1 of the Union of Burma Airways, registration XY-ABO, crashed in Gulf of Mottama (Martaban) en route from Mingaladon Airport to Mawlamyine (Moulmein) Airport.

In September 2013, Nok Air Mini started flights between the Thai border town Mae Sot and Mawlamyine.

[5] However, Nok Air Mini stopped its service due to the poor condition of the runway and facilities.

[6] Mawlamyine Airport was the location for a famous 1977 Burmese epic romance film Tein Oo Lay Pyay Maung Ko Say (Burmese: တိမ်ဦးလေပြေမောင့်ကိုစေ), starring Win Oo and Khin Yu May.