[2] His father allowed him to learn and play in the physics, biology and chemistry laboratories, where he enjoyed making lots of things from motors to mercury barometers.
Working at Bell Labs, Mathews wrote MUSIC, the first widely used program for sound generation, in 1957.
For the rest of the century, he continued as a leader in digital audio research, synthesis, and human-computer interaction as it pertains to music performance.
To our happy surprise, the students liked learning and using C. Primarily I believe it gives them a feeling of complete power to command the computer to do anything it is capable of doing.In 1961, Mathews arranged the accompaniment of the song "Daisy Bell" for an uncanny performance by computer-synthesized human voice, using technology developed by John Kelly, Carol Lochbaum, Joan Miller and Lou Gerstman of Bell Laboratories.
Author Arthur C. Clarke was coincidentally visiting friend and colleague John Pierce at the Bell Labs Murray Hill facility at the time of this remarkable speech synthesis demonstration and was so impressed that he later told Stanley Kubrick to use it in 2001: A Space Odyssey, in the climactic scene where the HAL 9000 computer sings while his cognitive functions are disabled.
[9] Mathews directed the Acoustical and Behavioral Research Center at Bell Laboratories from 1962 to 1985, which carried out research in speech communication, visual communication, human memory and learning, programmed instruction, analysis of subjective opinions, physical acoustics, and industrial robotics.
From 1974 to 1980 he was the Scientific Advisor to the Institute de Recherche et Coordination Acoustique/Musique (IRCAM), Paris, France, and from 1987 was Professor of Music (Research) at Stanford University.
He served as the Master of Ceremonies for the concert program of NIME-01, the inaugural conference on New interfaces for musical expression.