It was founded as Kaiser Wilhelm Institute for Brain Research in Berlin 1914, moved to Frankfurt-Niederrad in 1962 and more recently in a new building in Frankfurt-Riedberg.
The common research goal of the Institute is a mechanistic understanding of neurons and synapses, of the structural and functional circuits which they form, of the computational rules which describe their operations, and ultimately, of their roles in driving perception and behavior.
This includes interdisciplinary analyses at the molecular, cellular, multi-cellular, network and behavioral levels, often combined with theoretical approaches.
He was given some space in Moscow to carry out this work and two years later, a spacious and representative brick building that had been confiscated from an American business.
In 1927, Vogt gave a preliminary report on his findings in Moscow, concluding from his histological observations that Lenin must have been an athlete in associative thinking ("Assoziationsathlet") – a conclusion deemed farfetched by some of his neurologist colleagues and adversaries.
It was the world's largest and most modern brain research institute of its time, including Departments of Neurophysiology (Tönnies and Kornmüller), Neurochemistry (Marthe Vogt and Veit), Genetics (Timoféeff-Ressovsky), a Research Clinic (Soeken, Zwirner), and the Neuroanatomical Departments of Oskar and his wife Cécile Vogt.
In 1937, Nazi physician Hugo Spatz, a pupil of Franz Nissl, became Vogt's successor as director of the KWI for Brain Research and head of the Neuroanatomy Department.
Use of the eponym Hallervorden-Spatz syndrome is strongly discouraged due to Hallervorden and Spatz's involvement with the Nazi party and was replaced by the more descriptive terminology pantothenate kinase-associated neurodegeneration.
In the first decade of the new millennium, the MPG defined the analysis of neural networks as a central research topic for the institute.
The new departments took up work in the summer of 2009 and were initially located in interim facilities on the Science Campus "Riedberg" of the Frankfurt University.