As a research student he also worked in the lab of Sir Alan Fersht in Cambridge, UK at the MRC Laboratory for Molecular Biology (LMB) site.

[7] Patrick Cramer conducts basic research as the head of the Department of Molecular Biology[8] at the Max Planck Institute in Göttingen.

During his postdoctoral research with Roger Kornberg, Cramer determined the atomic, three-dimensional structure of RNA polymerase II, one of the biggest enzymes in the cell nucleus.

This work played a decisive role when the Nobel Prize in chemistry was awarded to Roger Kornberg in 2006 for studies of the molecular basis of eukaryotic transcription.

[9] The laboratory of Patrick Cramer investigates the molecular mechanisms and systemic principles of gene transcription in eukaryotic cells.

In April 2020, Dr Cramer's team at the Max Planck Institute of Biophysical Chemistry created the first "3D structure of the corona polymerase"[11] for the COVID-19 virus.

In addition, Cramer was one of the members of the scientific and technical advisory board of the Bavarian state government and worked on bioethics within the institute TTN.