Aspiring to become a singer since childhood, she began her music activities in 2003 upon passing an audition held by talent agency Horipro International.

[4] In 2003, at the age of 13, she participated in the 28th "HoriPro – Talent Scout Caravan – Love Music – Audition" (ホリプロ・タレントスカウトキャラバン・ラブミュージック・オーディション., Horipuro・Tarento Sukauto Kyaraban・Rabu Myūjikku・Ōdishon) and out of the 34,911 hopefuls, became one of the four who survived the final eliminations.

[9] She then released her third single "Fallin' in or Not" on September 27, 2006,[10] the title track of which was used as the ending theme for the anime series Love Get Chu.

[11] That same year, she gained popularity after being cast as the singing voice of the character Sheryl Nome in the anime television series Macross Frontier.

[12][13] She was invited to perform "Iteza Gogo Kuji Don't be late" and "Northern Cross" at Animelo Summer Live 2008.

[20] She then released the single "Kimi Shinitamō Koto Nakare" (キミシニタモウコトナカレ, Thou Shalt Not Die) on May 6, 2009; the title track is used as the opening theme to the anime series Shangri-La.

[35] She was scheduled to make an appearance at Animax Carnival Philippines in December 2013, but the event was cancelled as a result of the effects of Typhoon Haiyan.

[37] She then returned to the United States with a solo concert in San Francisco and a performance at Union Square for J-Pop Summit Festival 2014.

[43] She performed the song "Hikari Aru Basho e", which is used as the ending theme to the 2016 anime television series Izetta: The Last Witch.

[50] In September 2018, May'n and Megumi Nakajima, who played the role of Ranka Lee in Macross Frontier, released the single "Good job!

and a single titled "Kiba to Tsubasa" (牙と翼) on July 31, 2019,[52][53] which was used as the ending theme to the anime series Kochoki: Wakaki Nobunaga.

[4][58] In interviews with Anime News Network, May'n discussed her performance style and her experiences working with composers such as Kanno and Daisuke Asakura.

She stated that her initial preferred genres were R&B and dance music, but collaborating with Kanno made her realize that her voice fit rock songs more.

[59] May'n discussed the production of her song "You", used as the opening theme to the anime series The Ancient Magus' Bride, in a February 2018 interview with DaVinci News.