Directed by Jerome C. Pobocan, Jojo A. Saguin, and Erick C. Salud, it stars Zaijian Jaranilla, Albert Martinez, Dina Bonnevie, Tonton Gutierrez, Maja Salvador, Rayver Cruz, Dominic Ochoa, Desiree del Valle, Precious Lara Quigaman, Lito Pimentel, and Jaime Fabregas.

The show was developed following the success of Mga Anghel na Walang Langit and Princess Sarah as part of a lineup of family oriented Dreamscape Entertainment programs.

It was re-aired from March 16, 2020, to May 4, 2020, temporarily replacing Ang Probinsyano due to the community quarantines caused by the COVID-19 pandemic in the Philippines, which led ABS-CBN to suspend tapings of their ongoing drama series.

The story revolves around Santino (Zaijian Jaranilla), a wide-eyed young boy who was orphaned as a baby before being adopted and raised by Franciscans.

Living in the fictional town of Barangay Bagong Pag-asa, he eventually discovers the ability to see and speak with Jesus Christ, whom he fondly called “Bro”.

It currently holds the record as the country's highest-rated show of all time since Philippine television switched to a nationwide TV ratings system on the opening day of 2009.

[14][15][16] Entertainment columnist Nestor Torre of the Philippine Daily Inquirer said, "It must have been a big decision for the new show’s producers to get away from that downbeat view of life and come up with this Marcelino Pan Y Vino-inspired tale.

But it’s great to note that the gamble has paid off in a big way: May Bukas Pa has been enjoying very good ratings, proving what we’ve been saying all this time--that viewers want to be inspired by the dramas they watch."

However, he criticized the show's "religious" scenes as "poorly, shallowly staged," which he felt made genuine inspiration and devotion difficult to come by while viewing the series.

He adds, "Any director worth his salt would have sensed that the montage of healing needed good actors to make it meaningful and moving.

Zaijian Jaranilla, who portrays Angelito in the movie, has the ability to perform miracles such as healing the sick and communicating with spiritual beings.

Zaijian Jaranilla and Jaime Fabregas reprised their roles as Santino and Father Anthony to present the life of John Paul II and his significance for Filipinos.

In June 2019, Zaijian Jaranilla returned to Bacolor Church, where he revisited Bro (Jesus Christ) as part of ABS-CBN's 65th anniversary year-long celebration.