Mayfield was settled and platted in 1852 by Andreas Reiderer, an immigrant from Switzerland, who named it after the Swiss town of Maienfeld.

Mayfield received a post office in 1859, but quickly declined after the railroad stopped instead at Jackson, less than a mile to the east.

[5] On October 21, 2010, Mayfield made news when country music group Lady Antebellum performed a free concert at a Mobil station in the community.

The concert was an attempt to make amends for comments the group had made in an interview with Entertainment Weekly about a performance they had held in nearby Slinger before their rise to fame.

[6] Charles Kelley, a member of the group, stated that the comments were taken out of context and that the magazine neglected to print that they had said the performance in Slinger was "a lot of fun".