[8][9] Prime Minister Lee Hsien Loong inaugurated the station's groundbreaking ceremony on 6 September.

[10] Since the station is directly underneath Ang Mo Kio Avenue 4, its construction required traffic to be diverted in 15 phases.

[11][12] The sloping topography created height differences, which made it difficult to position the working platforms for the boring rigs and cranes to be used for the construction.

[11] Reflecting the area's heritage as a songbird-watching community, the station is decorated with 22 bird sculptures as part of an Art-in-Transit artwork by Song-Ming Ang.

Mayflower station is a designated Civil Defence (CD) shelter and contains a reinforced structure with blast doors.

During a chemical attack, the air vents of the station can be shut to prevent the circulation of toxic gases.