Mayo-Tsanaga is a department of Extreme-Nord Province in Cameroon.

The department covers an area of 4,393 km2 and at the 2005 Census had a total population of 699,971.

It is located within the Mandara Mountains, on the border with Nigeria.

The department is divided administratively into 7 communes and in turn into villages.

This Cameroon location article is a stub.