Mokolo is the departmental capital and largest city of the Mayo-Tsanaga department, in the Far North Province of Cameroon.

It is the fourth largest city in the Far North Province, after Maroua, Yagoua, and Kousséri.

In roughly 1947 the Muslim Lamido (traditional chief) Idrissou came to power in Mokolo.

Seemingly under pressure from the French administration of the area, Idrissou was obliged to release Mamoudou from his subordinate position.

To this day two Lamibé remain in Mokolo, separately but cooperatively serving both the Fulani and Mafa populations.

For a small fee, the Lamibé resolve problems and disputes, namely concerning marriages and divorce, inheritances, and some petty theft.

To the southwest of Mokolo, in the direction of the town Rumsiki, Kapsiki is the dominant language.

Mokolo has one internet café and two state-recognized financial institutions, the Mutuel Communautaire de Croissance, and a branch of Crédit du Sahel.

The primary crops grown in and around Mokolo include millets, soy, and peanuts.

The current serving Mayor, Damien Zokom, is a member of the RDPC party.

Mokolo is located on a paved road, 79 km to the west of Maroua, the regional capital.