In its current format, the Mayo Senior Championship begins in mid-summer.

Tooreen are the title holders, defeating Ballyhaunis by 1–21 to 0–22 after extra time in the 2024 final.

As of 2024, the competition is contested by teams representing Ballyhaunis, Castlebar, St. Ciaran's and Tooreen.

Ballina, Belmullet and Westport no longer compete in the Senior grade.

The trophy presented to the winners is the TJ Tyrrell Cup.