The mayor of Cagayan de Oro (Filipino: Punong lungsod ng Cagayan de Oro) is the head of the local government of the city who elected to three year terms.

The Mayor is also the executive head and leads the city's departments in executing the city ordinances and improving public services.

The Vice Mayor is the presiding officer of the 19-man Cagayan de Oro City Council, and he can only vote in case of a tiebreaker.

In case that the vice mayor dies while in office or is either removed or suspended, his duties will be carried out by the No.1 councilor, which is the councilor who garnered the most votes in the immediately preceding election.

The incumbent Vice Mayor is Jocelyn B. Rodriguez as of June 30, 2022.