Flores was born in Burgos, Tamaulipas, Mexico; her family moved to the United States when she was six years old before she gained citizenship at age 14.

Before her congressional campaign, she worked as a respiratory therapist and as chair of Hispanic outreach for the Hidalgo County Republican Party.

In June 2022, a special election in Texas's 34th congressional district was held after Democratic Representative Filemon Vela Jr. resigned.

Flores lost her campaign for a full term in the November 2022 midterm elections to Democrat Vicente Gonzalez in the district that was redrawn that year.

[6][7] Before her congressional campaigns and shortly after graduating from college, Flores worked in the Hidalgo County Republican Party as chair of Hispanic outreach.

[3] In tweets that she later deleted, Flores also promoted the false claim that the 2021 United States Capitol attack was "set up" by antifa members among the crowd during the riot.

[11][12] She ran her campaign appealing to Hispanic and Latino Americans and their disillusionment with the Democratic Party, which they have historically supported in South Texas.

[14] On March 1, 2022, Flores and Gonzalez won their respective partisan primaries and faced each other in the general election on November 8, 2022.

Flores initially blocked critics and changed the name of her social media account, but later said she had "no intention to mislead" and that the photos reminded her of her childhood upbringing in Mexico.

[34] Three days later, Flores spoke out about the Supreme Court opinion in Dobbs v. Jackson Women's Health Organization which overturned Roe v. Wade, calling the decision a "big win" and a "dream come true".

[9] Flores responded to the article, saying The New York Times knew "nothing about me or our culture" and that "I have received only hate from the liberal media".