The CX-60 was revealed on 8 March 2022 as part of Mazda's newly established "Large Product Group", which includes a range of larger vehicles using rear- and all-wheel drive layout.

[7][8] Due to the switch to the rear-wheel drive-based layout with longitudinal engine, Mazda is positioning the model upmarket towards vehicles from the more premium segment.

[11] Ceremony of the mass production of the CX-60 was held in late April 2022 in Japan, at Mazda Hofu Plant No.

The last function is an ingress/egress assistance that slides the steering wheel and seat automatically when the driver is entering or exiting the vehicle.

[13] The vehicle also features Kinematic Posture Control system which gently applies the brakes to the inside rear wheel to contain body roll.

Packages include Vision Technology, Luxury, Takumi, and SP; the former two are standard on the Azami grade.

[20] In March 2023, the Takumi grade was added to the range, powered by a 3.3L e-Skyactiv-D mild hybrid diesel (equipped with AWD).

It is offered with two powertrains: 2.5L e-Skyactiv PHEV petrol and 3.3L e-Skyactiv-D mild hybrid diesel (only for Homura grade).

In October 2022, a 3.3-litre Skyactiv-G turbocharged petrol engine was announced for some markets such as Australia, producing 209 kW (280 hp; 284 PS).

[31] The diesel engine equipped to the CX-60 features Distribution Controlled Partially Premixed Compression Ignition (DCPCI) technology.

An egg-shaped combustion chambers would split the premixed air-fuel mixture into two regions inside the piston bowl.

It consists of a 0.33 kWh lithium-ion battery, an inverter, a DC-to-DC converter and an electric motor/generator rated at 12 kW (16 hp; 16 PS) and 153 N⋅m (15.6 kg⋅m; 113 lb⋅ft) integrated into the transmission.

According to Australian publication CarExpert, the CX-60 straddles between "the mainstream and premium mid-size SUV segments", and looked like "it's gunning for the Germans".

The publication praised the efficiency of the plug-in hybrid model, while criticised the dynamics and stability of the CX-60 in comparison to the X3, concluding that "the CX-60 lacks that sense that it's been developed with absolute attention to detail.