After viewing a documentary on Tourette's, Morrow believed that individuals with TS "had a lament that they would never experience love because of this affliction".

... My movie is a tribute to anyone with an affliction who thinks they'll never find love.Morrow had played a person with TS in the film Other Voices and had already learned to portray tics, so "casting himself actually made things a bit easier".

[2] Linney was Morrow's first choice for the role of Callie because "he felt the kind of understanding and close rapport he knew would be necessary to bring the two lead characters to life".

[1] The New York Times wrote:[5] But the most grating conceit attempted by Mr. Morrow—who also directed and was a writer of the film—is to plunge inside Lyle's head by playing out several point-of-view scenes with a jittery camera.

The most facile development of Maze is that it treats Tourette's syndrome as a kind of Muse, a force that Lyle uses to spur him on.