Mazeppa is a populated place in Union County, Pennsylvania, United States, named in honor of Hetman Ivan Mazepa.

[1] The settlement was originally named Union, and later called Boyertown, after early settlers Samuel Boyer (1804 - 1874) and his wife Sarah.

[2] A name change was required by the Post Office in 1886, to eliminate confusion with Boyertown, Berks County.

Professor Clement E. Edmunds, being familiar with Lord Byron's poem Mazeppa, proposed the new name.

[1] This explains the name of Mazeppa's main street, Johnson Mill Road aka T628 aka Pennsylvania Quadrant Route 1001.