Mazin Saga: Mutant Fighter is a cross-genre game that blends side-scrolling beat 'em up and fighting playstyles where players take control of Koji Kabuto wielding the Mazinger Z armor through six stages, each one set in a different location across the world, to fight against enemies and powerful 'Bio Beasts' led by God Kaiser Hell.

During beat 'em up segments, Kabuto has the ability to execute special moves that deals damage to enemies on-screen by performing certain button combinations.

[2] Set in a different universe from the original Mazinger plot, the story begins in the year 1999 when God Kaiser Hell began an all-out invasion to control Earth using powerful giants known as 'Bio Beasts'.

[4] Artists Hidetoshi Fujioka, Naoyuki Hayakawa, Takehito Suzuki and Yasuo Wakatsuki created the pixel art, while Kunio-kun composer Kazuo Sawa scored the soundtrack and made the sound effects.

[7] Former Treasure member Tetsuhiko Kikuchi was inspired by Mazin Saga: Mutant Fighter to program the enemies manually rather than with mathematical algorithms during development of Gunstar Heroes.