The high school opened in 1980, at its current location, 101 East Hackberry Avenue McAllen, Texas, United States.

The school colors are Columbia blue and bright gold and the mascot is a mustang.

As of the 2023-2024 school years, the demographics of McAllen Memorial is 94.47% Hispanic, 3.16% White, 1.36% Asian, 0.63% Black, and 0.29% two or more races.

68.34% of students at McAllen Memorial is eligible to receive free or reduced lunch.

McAllen Memorial High School possesses one of the best regular season football records for the Rio Grande Valley with a 12–1 record in 2012 that included a 12-game win streak before a loss in the playoffs.