1872 – d. 1918), doctor, soldier and author of the famous First World War poem "In Flanders Fields".

Other families occupied the house until 1966, when a group of Guelph citizens purchased the building with the intention of preserving it as a museum.

This group formed the Lt. Col. John McCrae Birthplace Society and began to raise money for its restoration.

Summer activities include Poppy Push, Canada Day, Teddy Bear Picnic, History Camp and special teas in the garden.

In 2019, Guelph Museums announced that the House would again host a Backyard Theatre in July 2020, with a show that would not be a "literal telling of McCrae's story" but would contain a "significant amount of McCrae-specific content."