Throughout the late 1950s and early 1960s various colleges at the University of Guelph produced a half-hour radio program for CJOY in a sound booth in the Massey Hall drama practice theatre.

In that year, the station expanded its signal to 250 watts, enabling it to reach the Kitchener-Waterloo region.

In 2005 CFRU celebrated 25 years as an FM broadcaster in Canada with a series of concerts and community events.

On April 24, 2008 CFRU began broadcasting in a newly revamped on-air studio, updating the technological operations of the station to provide better and smoother programming.

CFRU broadcasts in English, Spanish, Mandarin, Cantonese, Turkish, Polish, Persian, and Dari.