South Bruce was created in 1999 as part of county-wide municipal restructuring.

The following year, both Mildmay-Carrick and Teeswater-Culross amalgamated again to form South Bruce, choosing Teeswater as the seat of the municipality.

South Bruce is one of two Ontario communities[2] being considered as a potential deep geological repository site for Canada's used nuclear fuel.

The two main population centres in South Bruce are Mildmay and Teeswater.

Other communities within the municipal boundaries are Carlsruhe, Deemerton, Formosa and Salem.