As of the 2017-2018 school year, the school had an enrollment of 748 students and 40.77 classroom teachers (on a FTE basis, for a student-teacher ratio of 18.35)[2] Notable alumni include Bo Rein and James D. Johnston, one of the inventors of the MP3 music format.

[4] Niles offers AP courses in Calculus AB and English Literature.

The school also offers Drama Club, English Festival, Key Club, National Honor Society, Prep Bowl, Students for the Environment, Science Olympiad, Speech and Debate, marching and concert bands, a women’s choir, concert choir, and an audition-required Chamber Choir called Belles and Beaux.

They held a 48-game regular season winning streak from 1959 to 1964 and were Ohio State Champions in 1961 and 1963.

The coach during this period, Tony Mason, went on to accept head coaching positions at University of Arizona and University of Cincinnati, and was elected to the Ohio High School Athletic Association Hall of Fame in 2002.