The sixth season of the long-running Australian outback drama McLeod's Daughters began airing on 15 February 2006 and concluded on 29 November 2006 after 32 episodes.

Bridie Carter (Tess), Simmone Jade Mackinnon (Stevie), Rachael Carpani (Jodi), Aaron Jeffery (Alex), Michala Banas (Kate), Brett Tucker (Dave), and Jonny Pasvolsky (Rob/Matt) all returned as main cast members from the previous season.

Zoe Naylor returns as a main cast member as Regan McLeod after being a recurring character in the previous season.

Dustin Clare joins as the recurring role of Riley Ward, but will act as a main cast member in the following season.

Daniel Feuerriegel (Leo) and Basia A'Hern (Rose) also return from the previous season in recurring roles and a story line together.