The company worked with numerous artists of the time, including Sarah Noble Ives, William Bruton, Edward P. Cogger, Enos Comstock, Frances Bassett Comstock, Georgina A. Davis, Henry Walker Herrick, Justin H. Howard, May Audubon Post, Victor Renwick, Ida Waugh, and Lois Williams.

[1] These artists created richly colored watercolors as well as pen-and-ink drawings, which were adapted to the printing processes for mass production.

John McLoughlin, Jr.'s death in 1905 caused the firm the loss of his artistic and commercial leadership, so in 1920 it was sold to the Milton Bradley Company.

During its time as a division of Milton Bradley, McLoughlin ceased game production although it continued publicating picture books.

McLoughlin Bros. enjoyed some success in the 1930s with mechanical paper toys called "Jolly Jump-Ups" but the it stopped production during World War II.