[11] Beyond India, the album sold over 300,000 copies across other parts of the world,[12] including Europe, the Middle East, Southeast Asia,[13] and Hong Kong.

[14] His performance of tracks from Me Against Myself on MTV Asia (alongside the Rishi Rich Project) had a television audience as large as 165 million viewers.

He praised the Asian musical influence, social commentary, and "well adjusted sense of humour", particularly the "hysterical crisis of integrity" shown in the title track "Me Against Myself" where "rapper Sean mercilessly derides his “pansy” singing alter ego".

"[21] Caroline Sullivan of The Guardian gave the album 3 out of 5 stars, praising "the Bollysoul arrangements that underscore his vocals", in reference to the fusion of Bollywood and soul music, especially in the song "Stolen".

[17] Peter Culshaw of The Telegraph referred to the album as "highly accomplished R&B, with minor Indian musical elements", but considered the best tracks in the album to be the hip hop tracks "You Don't Know Me" and "Me Against Myself" for their social commentary which deal with Sean's inner conflicts and the difficulties in "trying to make it as an Asian in the hip-hop arena."

In India, A. Vishnu of The Hindu stated that, "After having kick-started the `British sound with an Indian flavour' concept, Sean has created a cutting-edge formula, which appeals to Hip-hop fans and Bhangra enthusiasts alike."

"[22] In Malaysia, Kiren Kaur of New Straits Times also praised the album, referring to the songs "Eyes On You" and "Dance With You" in particular as "dance-floor favourites with the fusion of Desi rhythms with R&B tones.