The company, originally founded in January 1995 by Carl Pritzkat, Michael Rhodes, and Tony Travostino.

Since then it has worked to produce several hundred websites, with clients ranging from small nonprofits to large multi-national corporations.

For a period the company operated a string of gay sites under the moniker 'The Datalounge Network'.

[2] In January 1995, BMG Entertainment launched the Internet's first e-commerce site featuring an entire record label catalog, ecmrecords.com, which Mediapolis engineered and operated until late 2004.

In early 2010, Mediapolis was part of a team that purchased Publishers Weekly[4] from media conglomerate Reed Elsevier.