The Medicine Bow Union Pacific Depot was built 1912–1919 in Medicine Bow, Wyoming for the Union Pacific Railway.

It is a typical example of Union Pacific railway architecture with a hipped clay shingle roof with broad overhangs supported by brackets over a one-story wood-frame station structure.

The depot features a projecting bay designed to allow the station master to see incoming trains.

The western section of the building contained the waiting room, the station office and a baggage room, while the eastern section contained living quarters for the stationmaster and his family.

[1] The building is occupied by the Medicine Bow Museum.