It was established in 1863 and is published by Wiley-Blackwell on behalf of the Association for the Publication of the Journal of Internal Medicine.

The journal was established in 1863 as Medicinskt Archiv by Axel Key (Karolinska Institute).

[1] It covered the broad field of medicine, but accepted only contributions from Sweden written in Swedish.

However, it soon became more international and in 1869 it was renamed Nordiskt Medicinskt Arkiv, accepting articles from all Nordic countries in Swedish, Danish, and Norwegian, with abstracts in German.

Acta Medica Scandinavica covered general internal medicine and articles were later accepted also from the Netherlands.