She spent a number of years as a transport, but from the mid-1820s on she sailed between England and Canada.

Medusa first appeared in Lloyd's Register (LR) in 1813 with Hutchinson, master, Barrick, owner, and trade London transport.

[4] Lloyd's List reported on 23 September 1828 that Medusa, Sampson, master, had saved the crew of Evander at 44°N 48°W / 44°N 48°W / 44; -48.

Lloyd's List reported on 7 January 1834 that a Medusa had been abandoned at sea 60 miles off Flamborough Head.

On 1 January 1834 Clyde rescued all ten people on board Medusa, of Whitby as she was in a sinking state.