[1] In New Brunswick, the watershed of the Meduxnekeag is home to the richest, most diverse, and highest concentration of remnant sites of mature Appalachian Hardwood Forest in Atlantic Canada, containing many understorey plants rare or uncommon in the province.

The non-profit Meduxnekeag River Association Inc., based in Woodstock, has purchased, since 1998, approximately 2.25 square kilometres (500 acres) of forest, with more than 6 km (3.7 mi) of undeveloped shoreline.

Animals commonly found in the watershed include the moose, white-tailed deer, black bear, eastern coyote, red fox, raccoon, beaver, eastern chipmunk, striped skunk, red squirrel, snowshoe hare, mink, weasels, porcupine, and various mice, voles, and shrews.

[2] Significant sections of the Meduxnekeag are easy to canoe or kayak in high or medium water conditions (generally in May and June, and in September and October; also in July/August in wet summers).

Recreational canoeists traditionally put in just below the bridge on the North Branch (just above the confluence) and take out in downtown Woodstock, a half-day canoe depending on lingering time, passing through scenic, mostly forested country.