She created Veshya Anyay Mukti Parishad (VAMP),[2] a collective of people in sex work.

[4] Her experience showed her that organising into collectives is a useful method for bringing about empowerment, so she adopted this in the brothels she visited.

[2] Seshu went on to set up Vidrohi Mahila Manch, a collective of rural women that spreads awareness against HIV/AIDS, in 1997.

She had begun working with children of sex workers in 2004, and built a hostel for them called Mitra in Nipani, Karnataka, in 2009.

[10][11] These aims led to a controversy in 2005, when Seshu made the decision that SANGRAM would not support a United States government policy, the anti-prostitution pledge.