Her second novel, Just in Case (Penguin, 2006), won the annual Carnegie Medal from the British librarians recognising the year's best children's book published in the UK.

[5] She returned to the United States to finish her degree in 1980, and later moved to New York City for 9 years, where she worked in publishing and advertising.

What I Was, Rosoff's third novel, was published in August 2007, followed by two more collaborations with Blackall: Wild Boars Cook and Jumpy Jack and Googily.

Rosoff told Book Nerd, "The title comes from a joke about a dyslexic atheist walking up and down in front of a church with a sign that reads THERE IS NO DOG."

[11] In 2016, Rosoff won the Astrid Lindgren memorial award and the largest cash prize in children's literature for her entire catalog of work.