A new "Easy Scenario" mode decreases the overall difficulty of every title by granting many power-up items and abilities from the beginning, which saves the player from having to obtain them through normal means.

The original Game Boy Advance aspect ratio is preserved on the marginally larger Nintendo DS screens by placing a black border around the gameplay area in each title.

[5] In April 2010, Capcom announced the compilation's final North American release date of June 8, and elaborated that the game would feature new gameplay modes.

[6] A playable demo was made available to review websites just prior to the 2010 Electronic Entertainment Expo in Los Angeles and the final version was released in all territories in June 2010.

Arrangers and performers for the album include the series' original composer, such as Ippo Yamada, Ryo Kawakami, and Luna Umegaki.

[10] Reviewers commended the convenience of have all four Mega Man Zero games in one cartridge, and the value of owning them for the retail price of just one of the originals, but lamented that the compilation itself didn't have enough special features or enhancements.